MK 677 (Ibutamoren)
This is a non-peptidic, orally active and selective agonist of the growth hormone secretagogue (secretion-boosting) receptor. It mimics the action of ghrelin (the hormone that regulates appetite and the distribution and rate of use of energy) in the stomach, raising growth hormone and IGF-1 levels, but does not affect cortisol levels.
Human studies have shown it to increase both muscle mass and bone mineral density. Dosed at 25mg daily, Ibutamoren has been shown to increase IGF-1 levels by 60% in 6 weeks in humans. A 72% increase in IGF-1 levels was seen after 12 months.
MK 677 is non-hormonal and therefore requires no PCT after the cycle is over. It is best utilised in at least a 3 month cycle with dosage increasing each month. The optimal dosing time for MK 677 is at night directly before going to bed. You should start to notice a deeper sleep almost immediately. If you should wake up with numb or tingly hands, do not worry. This is a common side effect of the extra GH in the system.